EUS-guided Laser Ablation in Pancreatic Adenocarcinoma

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. Box , Beijing , China E-mail: xieliewen mail. Laser ablation inductively coupled plasma mass spectrometry LA-ICP-MS is a powerful micro-analytical tool that has been widely used in geoscience because of its ability to rapidly and precisely analyze isotopes in situ with a typical spatial resolution of 30—80 microns. Here we present a new method for U—Pb dating of zircon with a higher spatial resolution at a scale of 5. The new technique was evaluated by investigating six zircon standards with various known ages ranging from 32 Ma to Ma. We then further demonstrated the utility and robustness of the new high spatial resolution technique for its application to the real geological problem of complexly zoned zircons, to determine the age of the famous Dabie ultrahigh pressure metamorphism. We anticipate that the method will have a wide range of applications in high-resolution U—Pb dating of tiny or complex zircon grains with small cores or relatively narrow zones, with high efficiency and throughput in the geological research community.

GeoHistory Facility Laser Ablation ICPMS

Mass-spectrometry with inductively coupled plasma ion source is widely applied for the determination of elemental composition and isotope ratios of liquid and solid samples in geological, chemical, semiconductor and other technical sciences. It is a very flexible technique allowing to analyse the concentration of most elements of the periodic table down to a sub ppt-level in liquid samples and down to a sub ppb level in solid samples. It also allows for a high sample throughput and usually requires little sample preparation compared to the alternative techniques, such as TIMS or SIMS.

These applications include the laser ablation analysis of lithium tetraborate glass discs and minerals, as well as the analysis of a wide variety of natural solutions and dissolved solid samples mine tails, natural and underground waters, carbonates. It is also episodically used for the analysis of low element concentrations in solutions. Our laboratory has a wide experience in the analysis of geological samples and also carries out analyses for chemical and technical research institutions, as well as for commercial entities.

In this work we present a study of laser ablation (LA) restoration techniques and of thermoluminescence dating process (TL). The main aim of the work is to.

Increased analytical efficiency, through the elimination of He re-extractions and acid digestion, increases sample throughput and facilitates larger datasets. The spatially resolved selection of helium extraction locations eliminates the need for alpha-ejection corrections and allows for imperfect grains with inclusions, fractures, unusual morphologies, rounding, and surface frosting or coatings to be measured.

These advantages allow the effective analysis of detrital samples, which opens new avenues for geologic applications. Simultaneous collection of other chemical e. We demonstrate the accuracy and uncertainty of the measurement method using two measurement sessions. We determine the age of the Fish Canyon Tuff apatite reference material to be Our data reveal that zonation is a common feature in Fish Canyon Tuff apatite and can be resolved by LA-aHe methods to reduce dispersion.

UC Santa Barbara

Journal article. Hacker, B. Kylander-Clark, A. Andersen, T. Access the full text Link.

Endovenous laser ablation (EVLA) is a percutaneous technique that uses laser energy to ablate incompetent superficial veins. The axial veins.

Study record managers: refer to the Data Element Definitions if submitting registration or results information. This study evaluates the possibility of performing local therapy for PDAC using laser ablation of the tumor under ultrasonography EUS guidance. Safety of the procedure as well as post procedural quality of life will be also evaluated. Pancreatic adenocarcinoma PDAC is projected to be the second cause of cancer death in Western societies within a decade.

Despite these therapeutic approaches, the survival rate of unresectable pancreatic cancer remains disappointing. Recently, there is a growing interest in the development of alternative therapeutic approaches, which can work in parallel with standard chemoradiation therapy. In this context laser ablation has been reported to be effective in inducing coagulative necrosis of the tumour in absence of major adverse events. However, the available studies on the matter are limited by small sample size, lack of extended follow up and informations about the possibility to ablate the entire tumour mass.

Early adverse events will be those occurring during the procedure up to the first week after the ablation treatment. Late adverse events will be defined as any adverse event potentially related to the procedure occurring at the site of the primary tumor within 3 months after EUS LA treatment. Any potential adverse event such as pancreatitis, burns of the gastric or duodenal walls, bowel injury, or peritonitis will be recorded and graded according to the above-mentioned classification.

EORTC QLQ-C30 questionnaire evaluates 5 functions physical,role,cognitive, emotional, and social , 9 symptoms fatigue, pain, nausea and vomiting, dyspnea, loss of appetite, insomnia, constipation, diarrhea, and financial difficulties and the global health status. Questions regarding functions and symptoms are scored 1 to 4, with higher values representing a worse outcomes. Questions regarding global health status are scored 1 to 7, with higher values representing better outcomes.

Common lead-corrected laser ablation ICP-MS U-Pb systematics and geochronology of titanite

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In-situ rock slab U-Pb dating of perovskite by laser ablation – magnetic sectorfield ICP-MS: a new tool for diamond exploration. Mark T. Hutchison. 1,2 and Dirk.

CODEX is uniquely able to analyze the microscopic chemical and organic makeup of a sample in spatial context, while simultaneously determining its age. The instrument uses nanosecond laser pulses to ablate ions and neutrals, which can be measured directly or via secondary ionization. Recently, experiments using ultrashort pulse laser ablation have demonstrated significant improvement in measurement precision and accuracy, and new technological developments have resulted in significant reductions in the required size, power, and mass of lasers capable of producing these ultrashort pulses.

These improvements primarily have been demonstrated with laser ablation mass spectrometry LAMS , and in laser desorption inductively coupled plasma mass spectrometry, techniques that rely on the production of ions and micro-particulates. However, little is yet known about the production of neutrals using ultrashort pulses; some work suggests that fractionation of neutrals is reduced as well.

In this proposal we will rent and compare several femto- and pico- second lasers for ion and neutral production in our prototype instrument, and identify the optimal parameters for improving the accuracy of chemical, organic, and radiometric measurements.

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS)

Laser ablation has become a dominant technology for direct solid sampling in analytical chemistry. Laser ablation refers to the process in which an intense burst of energy delivered by a short laser pulse is used to sample remove a portion of a material. The advantages of laser-ablation chemical analysis include direct characterization of solids, no chemical procedures for dissolution, reduced risk of contamination or sample loss, analysis of very small samples not separable for solution analysis, and determination of spatial distributions of elemental composition.

Since then the word ablation has been adopted in the analytical community to describe the direct removal of material from samples of interest for subsequent chemical analysis.

Laser Ablation and Inductively Coupled Plasma-Mass Spectrometry. Time Team America used laser ablation to Radiocarbon Dating. The Radioactive Clock.

The systematics of U and Pb in zircons serve as one of the most important dating tools available in the geosciences. By submitting my data, I agree that Thermo Fisher Scientific and its affiliates “Thermo Fisher” managing the brands Life Technologies, Thermo Scientific, Unity Lab Services, Fisher Scientific may collect, process and use my data for advertising purposes relating to events, products, services and promotions.

Therefore, Thermo Fisher may store my data in US hosted, group wide shared applications of third party vendors e. Salesforce Inc. You can withdraw your consent to this data processing at any time by e-mailing analyze thermofisher. A high-performance multicollector ICPMS with high mass resolution capabilities for high precision isotope ratio measurements. It combines highest sensitivity and highest stability for all elements with an innovative multicollector technique.

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Common lead-corrected laser ablation ICP–MS U–Pb systematics and geochronology of titanite

Storey, C. Chemical Geology , pp. U-Pb geochronology using laser ablation ICP-MS is a fairly recently introduced technique and thus far its development has centred on zircon dating. A robust common Pb correction, necessitating the measurement of the stable Pb isotope is detailed.

We also apply LA-ICPMS to in situ dating of a variety of minerals (geochronology)​, isotopic analysis, 2D elemental mapping, and the.

Skip to search form Skip to main content You are currently offline. Some features of the site may not work correctly. DOI: Heaman and R. Hartlaub and R. Creaser and T. Machattie and C. This study reports U—Pb geochronological data for zircon obtained by laser ablation-multi-collector-ICP-MS using a new collector block design that includes three ion counters and twelve Faraday buckets.

The collector configuration allows for simultaneous detection of ion signals from mass U to Tl, an important factor for the achievement of highly precise and reproducible Pb—Pb and Pb—U ratios. View PDF. Save to Library.

Rapid U-series dating of young fossil corals by laser ablation MC-ICPMS

In-situ apatite laser ablation is challenging due to low concentrations of U and Th and thus a low abundance of radiogenic He. For apatite laser ablation to be effective the ultra-high-vacuum UHV line must have very low and consistent background levels of He. To reduce He background, samples are mounted in a UHV stable medium. Samples are ablated using a Resonetics nm excimer laser and liberated He is measured using a quadrupole mass spectrometer on the ASI Alphachron noble gas line; collectively this system is known as the Resochron.

The ablated sites are imaged using a Zygo Zescope optical profilometer and ablated pit volume measured using PitVol, a custom MatLab algorithm developed to enable precise and unbiased measurement of the ablated pit geometry. We use the well-characterized Durango apatite to demonstrate the accuracy and precision of the method.

Laser ablation inductively coupled plasma mass spectrometry (LA Key words: laser ablation rCP-MS, isotopic dating, accessory minerals, in-situ analysis.

Quantitative analyses can be obtained for most elements in the mass range amu practically 7 Li to U. Sample introduction to the ICP-MS system is setup for both liquid samples by nebulizer and solid material by laser ablation. The laboratory have a number of analytical procedures that are done routinely, which are listed below. We are always interested in developing new methods together with users of the laboratory, so please contact us to discuss your project. At the lab we use the software Iolite for data reduction.

We have methods set up for precise U-Pb ages for a number of uranium bearing accessory minerals such as zircon, monazite, baddeleyite, rutile, titanite and apatite among others. Trace element analyses are possible for most solid materials; the main limiting factor is weather materials can be ablated with the laser beam. Another factor is the quantification of element concentrations; this can be done if matrix matched material of known concentration is available.

However for many silicate materials, NIST standard glasses are sufficient for element quantification. Below example are from an otolith fish ear-stone and a clino-pyroxene.

Step-by-Step Overview of Laser Ablation Treatment

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